A study, published in the BMJ, finds those who take ACE inhibitors are 14% more likely to develop lung cancer.
The study took place in the UK and studied close to 1 million patients over the time period of 1995-2015 and found the longer one took the blood pressure medication, the higher the risk in developing lung cancer.
Over 100 million adults in the US have high blood pressure, and ACE inhibitors are one of the most popular treatments due to their low-cost and efficacy.
They work by blocking an enzyme in the angiotensin-renin system, resulting in blood vessel relaxation and a lowering of blood pressure.
One side effect, however, may be coughing due to the accumulation of bradykinin, and researchers believe this could be the culprit in the increased risk of lung cancer.
Common ACE inhibitors include ramipril, captopril, lisinopril and benazepril.
However, since lung cancer is the most common type of cancer, blood pressure is one of the most common types of conditions and ACE inhibitors are one the most commonly used blood pressure medications, the association may be coincidental and not a cause and effect.
More research needs to be done on the long-term use of the medications as uncontrolled blood pressure can link to heart disease, stroke and dementia.